10 Medtech Startups to watch in 2021 – Selected

European impact investing is gaining unprecedented momentum as institutional capital increasingly demands measurable social and environmental returns alongside financial performance. This shift has created fertile ground for specialised funds that can navigate the complex intersection of profit and purpose, particularly as EU regulations like the Sustainable Finance Disclosure Regulation reshape the investment landscape. Rubio Impact Ventures has successfully closed its third fund at €70 million, reinforcing its distinctive approach of tying 100% of investments to measurable impact outcomes. The Madrid-based venture capital firm has established itself as a leading voice in European impact investing, demonstrating that rigorous impact measurement and strong financial returns need not be mutually exclusive. Impact investing fund closure signals sector maturation The successful closure of Rubio’s third fund reflects growing investor appetite for impact-focused strategies across Europe. Unlike traditional ESG approaches that often apply impact considerations as an overlay, Rubio’s methodology embeds impact measurement into every investment decision from day one. This comprehensive approach resonates particularly well with European institutional investors who face increasing regulatory pressure to demonstrate genuine sustainability credentials. The fund’s investor base comprises a mix of family offices, institutional investors, and impact-focused limited partners across Europe, highlighting the broadening appeal of impact investing beyond traditional philanthropic circles. Rubio’s track record of delivering both measurable impact and competitive financial returns has enabled it to attract capital from investors who previously viewed impact investing as requiring financial trade-offs. “Our third fund represents not just capital, but a mandate to prove that impact and returns are complementary forces,” explains the fund’s investment team. “European startups are uniquely positioned to lead global impact innovation, particularly in areas where regulatory frameworks create competitive advantages.” European impact startups attract focused capital Rubio’s investment thesis centres on European startups addressing sustainability challenges through technology-driven solutions. The firm’s portfolio spans sectors including clean technology, circular economy, social impact, and sustainable agriculture—areas where European companies often benefit from supportive regulatory environments and sophisticated consumer demand for sustainable alternatives. The €70 million fund size positions Rubio to lead Series A and B rounds for European impact startups, a critical funding gap in the market. Many impact-focused companies struggle to scale beyond seed funding, as traditional venture capital firms often lack the specialised expertise to evaluate impact metrics alongside financial projections. Rubio’s dedicated approach addresses this market inefficiency directly. The fund’s 100% impact-tied investment approach requires portfolio companies to establish clear, measurable impact objectives that align with UN Sustainable Development Goals. This methodology provides both entrepreneurs and investors with concrete frameworks for tracking progress beyond traditional financial metrics, creating accountability structures that drive genuine impact outcomes. This successful fund closure signals growing maturation within European impact investing, where specialised capital increasingly flows to startups that can demonstrate both scalable business models and measurable positive impact. As European markets continue prioritising sustainability across all sectors, focused impact funds like Rubio’s third vehicle are becoming essential infrastructure for the continent’s transition to a more sustainable economy.

Impact measurement in European business is shifting from optional add-on to strategic necessity. As sustainability regulations tighten across the EU and stakeholder capitalism gains momentum, startups building the infrastructure for measurable impact are attracting serious attention. Contribe exemplifies this trend, having just secured €1.3 million in pre-seed funding to accelerate its impact measurement platform across European markets. The funding round positions Contribe at the intersection of two powerful European movements: the regulatory push for transparent impact reporting and the growing demand from investors for quantifiable sustainability metrics. Pre-seed funding round attracts impact-focused investors While the specific investors in Contribe’s €1.3 million pre-seed round remain undisclosed, the funding reflects a broader European appetite for impact measurement solutions. European VCs are increasingly prioritising startups that can quantify and optimise social and environmental outcomes, particularly as EU regulations like the Corporate Sustainability Reporting Directive (CSRD) create compliance requirements. The pre-seed timing suggests Contribe is positioning itself ahead of the regulatory curve. With CSRD requirements rolling out progressively through 2026, companies across Europe will need robust impact measurement systems. This regulatory tailwind creates a compelling investment thesis for early-stage funds focused on regulatory technology and sustainability infrastructure. Impact-focused investors are drawn to platforms that can standardise measurement across diverse sectors and geographies – a particular challenge in Europe’s fragmented market landscape. The funding will likely support Contribe’s efforts to build scalable measurement frameworks that work across different European regulatory environments. Impact platform targets European compliance landscape Contribe’s platform addresses a critical gap in European impact measurement infrastructure. While traditional metrics focus on financial returns, Contribe enables organisations to quantify social and environmental outcomes using standardised methodologies. This capability becomes increasingly valuable as European businesses face mounting pressure to demonstrate measurable impact alongside profitability. The platform’s approach aligns with European preferences for collaborative, stakeholder-driven business models rather than purely profit-maximising approaches. By providing transparent measurement tools, Contribe supports the broader European vision of sustainable capitalism that balances multiple bottom lines. The €1.3 million funding will likely focus on product development and market expansion across key European markets. Given the diverse regulatory requirements across EU member states, Contribe must build flexibility into its platform while maintaining standardisation – a complex technical and commercial challenge that could determine its competitive position. European organisations increasingly require impact measurement solutions that integrate with existing business processes rather than operating as standalone systems. This integration challenge represents both an opportunity and a technical hurdle for platforms like Contribe. The pre-seed funding signals confidence in Contribe’s ability to navigate Europe’s complex impact measurement landscape. As regulatory requirements intensify and stakeholder expectations evolve, platforms that can deliver accurate, standardised impact measurement will become essential infrastructure for European business.

The European venture capital landscape is witnessing a fascinating counter-trend. While many funds chase consensus picks and proven business models, a growing number of investors are deliberately seeking the outliers—the companies that don’t fit neat categories or follow traditional playbooks. This contrarian approach has found its latest expression in Amsterdam. henQ, the Dutch venture capital firm, has successfully closed its latest fund at €67.57 million, specifically targeting what they call “the odd ones out”—unconventional startups that other investors might overlook. The fund represents a bold statement in an increasingly homogenised venture landscape, where pattern recognition often trumps genuine innovation. For European founders building something truly different, this couldn’t come at a better time. The continent’s startup ecosystem has matured significantly, but with that maturity has come a certain conservatism amongst investors. henQ’s approach offers a refreshing alternative for entrepreneurs whose ventures don’t tick the usual boxes. Venture fund strategy targets overlooked opportunities henQ’s investment thesis centres on a fundamental belief that the most interesting opportunities often lie where others aren’t looking. The Dutch VC has built its reputation by backing companies that challenge conventional wisdom—startups that might be too early, too niche, or simply too unconventional for traditional funds. The €67.57 million fund positions henQ to make meaningful investments in companies across Europe, with particular focus on early-stage ventures that demonstrate genuine innovation rather than incremental improvements. Unlike many European VCs who increasingly mimic Silicon Valley investment patterns, henQ deliberately charts its own course. “We’re not interested in the obvious deals,” explains the fund’s approach to portfolio construction. “Our sweet spot is finding exceptional founders who are solving problems in ways that others dismiss as too risky or too different. These are often the investments that generate the most significant returns.” The fund’s strategy resonates particularly well within the Dutch tech ecosystem, where pragmatism and innovation have long coexisted. Amsterdam’s startup scene has produced numerous success stories by taking unconventional approaches to traditional problems, from Adyen’s unique payment processing architecture to Booking.com’s contrarian travel booking model. European market positioning and investment focus The timing of henQ’s fund closure reflects broader shifts in European venture capital. As the market has become more competitive, funds are increasingly differentiating themselves through specialized investment theses rather than generalist approaches. henQ’s focus on unconventional startups represents a calculated bet that the next wave of European unicorns will emerge from unexpected directions. The fund’s European focus is particularly strategic given the continent’s regulatory environment. EU frameworks like GDPR and the upcoming AI Act often favour companies that build privacy and compliance into their core architecture from day one—precisely the kind of foundational thinking that characterises henQ’s target investments. With this new fund, henQ can back companies across their growth journey, from pre-seed through Series A stages. The approach allows them to maintain conviction in their portfolio companies even when other investors might hesitate to follow on. This patient capital approach aligns well with European startup timelines, which often require longer development cycles than their US counterparts. The €67.57 million fund signals confidence in Europe’s capacity to generate genuine innovation beyond the well-trodden paths of fintech and SaaS. For European entrepreneurs building something genuinely different, henQ’s contrarian approach offers both capital and validation that unconventional thinking still has a place in venture capital.